The Association Between Urinary Concentrations of Organophosphate Metabolites and Asthma-Related Outcomes Among Schoolchildren From Informal Settlements

Objectives: There is inconsistent evidence on the relationship between pesticide exposure and childhood respiratory outcomes in non-agricultural settings. This study investigated association organophosphate (OP) asthma-related children residing four informal settlements. Methods: The was a longitudinal of 590 schoolchildren, with 12 months follow-up period. A standardised questionnaire adopted from International Study Asthma Allergies Childhood administered to caregivers for child’s symptoms household characteristics. Spirometry fractional-exhaled nitric oxide, including phadiatop test (atopy status) urinary dialkyl phosphate (DAP) metabolites were measured at baseline follow-up. DAP included diethylphosphate (DEP) dimethyl (DMP) dimethylthiophosphate (DMTP) only baseline. Results: mean ages schoolchildren 9.9 ± 0.91 years overal incidence proportions new doctor diagnosed asthma 2.2%. No consistent patterns increased risk increasing concentrations found multivariate analysis. Conclusion: Future studies longer periods repeated OP biomonitoring are recommended.